Drug interactions
Meclofenamate + Methylprednisolone
Severity: Moderate
Meclofenamate and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a systemic corticosteroid with an NSAID increases the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is higher in older patients, with high steroid doses and with longer duration.
What this interaction means in plain words
Meclofenamate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury: NSAID prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for gastroprotection; counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Meclofenamate with Methylprednisolone?
MediHelp rates the interaction as moderate. Meclofenamate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a systemic corticosteroid with an NSAID increases the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is higher in older patients, with high steroid doses and with longer duration.
How serious is the interaction between Meclofenamate and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for gastroprotection; counsel patients to report black stools or abdominal pain.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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