Drug interactions
Meclofenamate + Metolazone
Severity: Moderate
Meclofenamate and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce the diuretic and antihypertensive effects of metolazone. Together they may also increase the risk of kidney injury, particularly in volume-depleted patients.
What this interaction means in plain words
Meclofenamate and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and fluid retention and lowers renal blood flow, opposing diuretic action.
What to do
Monitor blood pressure, fluid status and renal function, and use the lowest effective NSAID dose for the shortest time. Consider an alternative analgesic in patients with heart failure or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Meclofenamate with Metolazone?
MediHelp rates the interaction as moderate. Meclofenamate and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce the diuretic and antihypertensive effects of metolazone. Together they may also increase the risk of kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Meclofenamate and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function, and use the lowest effective NSAID dose for the shortest time. Consider an alternative analgesic in patients with heart failure or renal impairment.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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