Drug interactions
Meclofenamate + Sotalol
Severity: Moderate
Meclofenamate and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce the antihypertensive effect of beta-blockers. They can also impair renal function, which may lead to sotalol accumulation and QT-related risk.
What this interaction means in plain words
Meclofenamate and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and water retention and may reduce renal clearance of sotalol.
What to do
Monitor blood pressure and renal function during prolonged NSAID use. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Meclofenamate with Sotalol?
MediHelp rates the interaction as moderate. Meclofenamate and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can reduce the antihypertensive effect of beta-blockers. They can also impair renal function, which may lead to sotalol accumulation and QT-related risk.
How serious is the interaction between Meclofenamate and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during prolonged NSAID use. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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