Drug interactions
Meclofenamic acid + Moxifloxacin
Severity: Moderate
Meclofenamic acid and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones may provoke CNS stimulation and seizures, and NSAIDs can potentiate this in predisposed patients. The risk is greatest with high doses or existing seizure risk factors.
What this interaction means in plain words
Meclofenamic acid and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, possibly potentiated by NSAIDs; not fully established.
What to do
Avoid in patients with epilepsy or prior seizures and consider alternative agents. Counsel patients to report tremor, agitation or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Moxifloxacin?
MediHelp rates the interaction as moderate. Meclofenamic acid and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones may provoke CNS stimulation and seizures, and NSAIDs can potentiate this in predisposed patients. The risk is greatest with high doses or existing seizure risk factors.
How serious is the interaction between Meclofenamic acid and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or prior seizures and consider alternative agents. Counsel patients to report tremor, agitation or seizures.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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