Drug interactions
Meclofenamic acid + Pegaspargase
Severity: Moderate
Meclofenamic acid and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulation abnormalities and thrombocytopenia, and meclofenamic acid inhibits platelet function and irritates the gastric mucosa. Together they may increase the risk of bleeding.
What this interaction means in plain words
Meclofenamic acid and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive effects on hemostasis: asparaginase-related reduction in clotting factors and NSAID platelet inhibition.
What to do
Monitor coagulation parameters and platelet counts, and watch for bleeding. Avoid NSAIDs when platelets are low or coagulopathy is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Meclofenamic acid with Pegaspargase?
MediHelp rates the interaction as moderate. Meclofenamic acid and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulation abnormalities and thrombocytopenia, and meclofenamic acid inhibits platelet function and irritates the gastric mucosa. Together they may increase the risk of bleeding.
How serious is the interaction between Meclofenamic acid and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters and platelet counts, and watch for bleeding. Avoid NSAIDs when platelets are low or coagulopathy is present.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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