Drug interactions
Meclofenamic acid + Piroxicam
Severity: Major
Meclofenamic acid and Piroxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together adds no therapeutic benefit and raises the risk of gastrointestinal ulceration, bleeding, and kidney injury. Platelet inhibition and renal effects are additive.
What this interaction means in plain words
Meclofenamic acid and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meclofenamic acid belongs to Musculoskeletal; Piroxicam belongs to Musculoskeletal.
Why it happens
Both drugs inhibit cyclooxygenase, so their effects on platelets, gastric mucosa and renal prostaglandins are additive.
What to do
Avoid combining two systemic NSAIDs; choose a single agent at the lowest effective dose. If an overlap occurs, monitor for GI bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Meclofenamic acid with Piroxicam?
MediHelp rates the interaction as major. Meclofenamic acid and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together adds no therapeutic benefit and raises the risk of gastrointestinal ulceration, bleeding, and kidney injury. Platelet inhibition and renal effects are additive.
How serious is the interaction between Meclofenamic acid and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two systemic NSAIDs; choose a single agent at the lowest effective dose. If an overlap occurs, monitor for GI bleeding and renal function.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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