Drug interactions
Meclofenamic acid + Potassium iodide
Severity: Moderate
Meclofenamic acid and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies a potassium load, and NSAIDs reduce renal potassium excretion, so serum potassium can rise. The risk is greatest in renal impairment or in patients taking other potassium-raising drugs.
What this interaction means in plain words
Meclofenamic acid and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Potassium iodide belongs to Endocrine.
Why it happens
NSAID-induced suppression of renin-aldosterone and renal prostaglandins reduces potassium excretion, adding to the potassium load.
What to do
Monitor serum potassium and renal function, especially with prolonged or high-dose potassium iodide therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Meclofenamic acid with Potassium iodide?
MediHelp rates the interaction as moderate. Meclofenamic acid and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide supplies a potassium load, and NSAIDs reduce renal potassium excretion, so serum potassium can rise. The risk is greatest in renal impairment or in patients taking other potassium-raising drugs.
How serious is the interaction between Meclofenamic acid and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially with prolonged or high-dose potassium iodide therapy.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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