Drug interactions
Meclofenamic acid + Rivaroxaban
Severity: Major
Meclofenamic acid and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with rivaroxaban increase the likelihood of clinically significant bleeding, especially gastrointestinal. The combination should be avoided where possible.
What this interaction means in plain words
Meclofenamic acid and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meclofenamic acid belongs to Musculoskeletal; Rivaroxaban belongs to Cardiovascular.
Why it happens
NSAIDs inhibit platelet function and damage gastric mucosa, adding to the anticoagulant effect of factor Xa inhibition.
What to do
Avoid concurrent use if possible and choose paracetamol for analgesia. If needed, use the lowest NSAID dose briefly with gastroprotection and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Meclofenamic acid with Rivaroxaban?
MediHelp rates the interaction as major. Meclofenamic acid and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs given with rivaroxaban increase the likelihood of clinically significant bleeding, especially gastrointestinal. The combination should be avoided where possible.
How serious is the interaction between Meclofenamic acid and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible and choose paracetamol for analgesia. If needed, use the lowest NSAID dose briefly with gastroprotection and monitor for bleeding and hemoglobin.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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