Drug interactions
Mefenamic acid + Ofloxacin
Severity: Moderate
Mefenamic acid and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may increase CNS stimulation and the risk of seizures. Mefenamic acid has its own seizure-provoking potential. Patients with epilepsy, renal impairment or elevated drug exposure are most at risk.
What this interaction means in plain words
Mefenamic acid and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold, with fluoroquinolone GABA-A receptor antagonism possibly potentiated by NSAIDs.
What to do
Avoid in patients with seizure history or other CNS risk factors. Otherwise monitor for CNS excitation and prefer a different analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Mefenamic acid with Ofloxacin?
MediHelp rates the interaction as moderate. Mefenamic acid and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may increase CNS stimulation and the risk of seizures. Mefenamic acid has its own seizure-provoking potential. Patients with epilepsy, renal impairment or elevated drug exposure are most at risk.
How serious is the interaction between Mefenamic acid and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure history or other CNS risk factors. Otherwise monitor for CNS excitation and prefer a different analgesic.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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