Drug interactions
Mefenamic acid + Prednisolone
Severity: Moderate
Mefenamic acid and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a corticosteroid and an NSAID raises the risk of peptic ulcers and gastrointestinal bleeding. The risk is highest in older patients and with prolonged use.
What this interaction means in plain words
Mefenamic acid and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Prednisolone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury through prostaglandin inhibition and impaired mucosal healing.
What to do
Limit dose and duration, and consider gastroprotection with a proton pump inhibitor in patients at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Prednisolone?
MediHelp rates the interaction as moderate. Mefenamic acid and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a corticosteroid and an NSAID raises the risk of peptic ulcers and gastrointestinal bleeding. The risk is highest in older patients and with prolonged use.
How serious is the interaction between Mefenamic acid and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit dose and duration, and consider gastroprotection with a proton pump inhibitor in patients at risk.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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