Drug interactions
Mefenamic acid + Streptomycin
Severity: Moderate
Mefenamic acid and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can lower renal clearance of aminoglycosides, mainly shown in neonates, which may raise drug levels. Higher exposure increases the risk of ototoxicity and nephrotoxicity. Evidence for mefenamic acid in adults is limited.
What this interaction means in plain words
Mefenamic acid and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular filtration and aminoglycoside excretion.
What to do
Monitor renal function and streptomycin levels, and watch for hearing or vestibular symptoms. Use an alternative analgesic in neonates or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Mefenamic acid with Streptomycin?
MediHelp rates the interaction as moderate. Mefenamic acid and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can lower renal clearance of aminoglycosides, mainly shown in neonates, which may raise drug levels. Higher exposure increases the risk of ototoxicity and nephrotoxicity. Evidence for mefenamic acid in adults is limited.
How serious is the interaction between Mefenamic acid and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels, and watch for hearing or vestibular symptoms. Use an alternative analgesic in neonates or renal impairment.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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