Drug interactions
Mefenamic acid + Tenecteplase
Severity: Major
Mefenamic acid and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a thrombolytic, and NSAIDs impair platelet function, so combined use raises the risk of serious bleeding. Concern is greatest during and shortly after thrombolysis.
What this interaction means in plain words
Mefenamic acid and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mefenamic acid belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive impairment of hemostasis from NSAID-induced platelet dysfunction plus fibrinolysis.
What to do
Avoid NSAIDs around thrombolytic treatment unless clearly necessary. Monitor for bleeding at puncture sites and in the gastrointestinal and intracranial compartments.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Mefenamic acid with Tenecteplase?
MediHelp rates the interaction as major. Mefenamic acid and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a thrombolytic, and NSAIDs impair platelet function, so combined use raises the risk of serious bleeding. Concern is greatest during and shortly after thrombolysis.
How serious is the interaction between Mefenamic acid and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs around thrombolytic treatment unless clearly necessary. Monitor for bleeding at puncture sites and in the gastrointestinal and intracranial compartments.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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