Drug interactions
Mefenamic acid + Tolmetin
Severity: Major
Mefenamic acid and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds toxicity without added efficacy, raising the risk of gastrointestinal bleeding and ulceration, kidney injury and fluid retention.
What this interaction means in plain words
Mefenamic acid and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mefenamic acid belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive COX inhibition causes cumulative gastric, platelet and renal prostaglandin suppression.
What to do
Avoid using the two together and keep to a single NSAID at the lowest effective dose. Use gastroprotection if NSAID therapy is needed in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Tolmetin?
MediHelp rates the interaction as major. Mefenamic acid and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds toxicity without added efficacy, raising the risk of gastrointestinal bleeding and ulceration, kidney injury and fluid retention.
How serious is the interaction between Mefenamic acid and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together and keep to a single NSAID at the lowest effective dose. Use gastroprotection if NSAID therapy is needed in high-risk patients.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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