Drug interactions
Mefenamic acid + Valganciclovir
Severity: Minor
Mefenamic acid and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valganciclovir is converted to ganciclovir, which is renally eliminated by filtration and tubular secretion. NSAIDs may compete for secretion and impair renal perfusion, which could raise ganciclovir exposure. The clinical effect is poorly documented.
What this interaction means in plain words
Mefenamic acid and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mefenamic acid belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion and NSAID-related reduction in renal function lower ganciclovir clearance.
What to do
Monitor renal function and blood counts. Adjust the valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Mefenamic acid with Valganciclovir?
MediHelp rates the interaction as minor. Mefenamic acid and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valganciclovir is converted to ganciclovir, which is renally eliminated by filtration and tubular secretion. NSAIDs may compete for secretion and impair renal perfusion, which could raise ganciclovir exposure. The clinical effect is poorly documented.
How serious is the interaction between Mefenamic acid and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts. Adjust the valganciclovir dose to creatinine clearance.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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