Drug interactions
Mefloquine + Nifedipine
Severity: Minor
Mefloquine and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine is not an established CYP3A4 inhibitor, so an important rise in nifedipine concentrations is unlikely. Additive hypotension or conduction effects are possible but expected to be small.
What this interaction means in plain words
Mefloquine and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mefloquine belongs to Anti Parasitic; Nifedipine belongs to Cardiovascular.
Why it happens
Possible minor pharmacodynamic additivity; no established pharmacokinetic mechanism.
What to do
No dose change is needed routinely; monitor blood pressure and heart rate at the start of combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Mefloquine with Nifedipine?
MediHelp rates the interaction as minor. Mefloquine and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefloquine is not an established CYP3A4 inhibitor, so an important rise in nifedipine concentrations is unlikely. Additive hypotension or conduction effects are possible but expected to be small.
How serious is the interaction between Mefloquine and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely; monitor blood pressure and heart rate at the start of combined use.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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