Drug interactions
Mefloquine + Pazopanib
Severity: Major
Mefloquine and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is a P-glycoprotein substrate and mefloquine inhibits P-glycoprotein, so pazopanib exposure may rise. Pazopanib itself prolongs QT and can cause hepatotoxicity, and mefloquine adds QT effects.
What this interaction means in plain words
Mefloquine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mefloquine belongs to Anti Parasitic; Pazopanib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by mefloquine raising pazopanib levels, plus additive QT prolongation.
What to do
Avoid combined use if possible. If necessary, monitor the ECG, electrolytes and liver function tests and consider pazopanib dose reduction for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Mefloquine with Pazopanib?
MediHelp rates the interaction as major. Mefloquine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib is a P-glycoprotein substrate and mefloquine inhibits P-glycoprotein, so pazopanib exposure may rise. Pazopanib itself prolongs QT and can cause hepatotoxicity, and mefloquine adds QT effects.
How serious is the interaction between Mefloquine and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use if possible. If necessary, monitor the ECG, electrolytes and liver function tests and consider pazopanib dose reduction for toxicity.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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