Drug interactions
Mefloquine + Selpercatinib
Severity: Moderate
Mefloquine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, as can mefloquine. Together they may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Mefloquine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Selpercatinib belongs to Oncology.
Why it happens
Additive QTc prolongation through pharmacodynamic effects.
What to do
Monitor ECG and potassium, magnesium and calcium at baseline and periodically. Interrupt or reduce selpercatinib per labeling, or switch the antimalarial, if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Mefloquine with Selpercatinib?
MediHelp rates the interaction as moderate. Mefloquine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, as can mefloquine. Together they may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Mefloquine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium, magnesium and calcium at baseline and periodically. Interrupt or reduce selpercatinib per labeling, or switch the antimalarial, if QTc becomes markedly prolonged.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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