Drug interactions
Melatonin + Metaproterenol
Severity: Minor
Melatonin and Metaproterenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin promotes sleep whereas metaproterenol is a beta-agonist that may cause nervousness and insomnia. The combined effect on alertness is unpredictable and of little clinical significance.
What this interaction means in plain words
Melatonin and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on alertness; no established interaction mechanism.
What to do
No routine action is needed. Review the timing of bronchodilator doses if sleep is disturbed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Metaproterenol?
MediHelp rates the interaction as minor. Melatonin and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin promotes sleep whereas metaproterenol is a beta-agonist that may cause nervousness and insomnia. The combined effect on alertness is unpredictable and of little clinical significance.
How serious is the interaction between Melatonin and Metaproterenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Review the timing of bronchodilator doses if sleep is disturbed.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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