Drug interactions
Melatonin + Methylenedioxymethamphetamine
Severity: Minor
Melatonin and Methylenedioxymethamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a stimulant that disrupts sleep, while melatonin is sedating, so effects may partly offset. MDMA is an illicit drug with significant independent toxicity, and no meaningful interaction data exist.
What this interaction means in plain words
Melatonin and Methylenedioxymethamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on arousal; no established mechanism of interaction.
What to do
Do not use melatonin to counteract MDMA effects. Counsel about MDMA risks such as hyperthermia and serotonin toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Melatonin and Methylenedioxymethamphetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Methylenedioxymethamphetamine?
MediHelp rates the interaction as minor. Melatonin and Methylenedioxymethamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MDMA is a stimulant that disrupts sleep, while melatonin is sedating, so effects may partly offset. MDMA is an illicit drug with significant independent toxicity, and no meaningful interaction data exist.
How serious is the interaction between Melatonin and Methylenedioxymethamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use melatonin to counteract MDMA effects. Counsel about MDMA risks such as hyperthermia and serotonin toxicity.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
