Drug interactions
Melatonin + Motherwort
Severity: Minor
Melatonin and Motherwort: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort is traditionally used as a mild sedative, and combined with melatonin it may increase drowsiness. Evidence on motherwort is very limited.
What this interaction means in plain words
Melatonin and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive sedative effects.
What to do
Monitor for excessive sleepiness and counsel on driving. Stop one product if sedation is bothersome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Motherwort?
MediHelp rates the interaction as minor. Melatonin and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort is traditionally used as a mild sedative, and combined with melatonin it may increase drowsiness. Evidence on motherwort is very limited.
How serious is the interaction between Melatonin and Motherwort?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sleepiness and counsel on driving. Stop one product if sedation is bothersome.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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