Drug interactions
Melatonin + Orphenadrine
Severity: Moderate
Melatonin and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. Melatonin may add to sedation and impaired alertness, especially in older adults.
What this interaction means in plain words
Melatonin and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for oversedation and confusion, particularly in older patients. Counsel against driving and consider lowering one dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Orphenadrine?
MediHelp rates the interaction as moderate. Melatonin and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. Melatonin may add to sedation and impaired alertness, especially in older adults.
How serious is the interaction between Melatonin and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and confusion, particularly in older patients. Counsel against driving and consider lowering one dose.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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