Drug interactions
Melatonin + Papaveretum
Severity: Moderate
Melatonin and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opioid preparation that causes sedation and respiratory depression. Melatonin has mild sedative properties and may add to drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Melatonin and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Monitor for excessive sedation and reduced alertness, particularly at treatment initiation or dose increases. Advise patients to avoid driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Papaveretum?
MediHelp rates the interaction as moderate. Melatonin and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum is an opioid preparation that causes sedation and respiratory depression. Melatonin has mild sedative properties and may add to drowsiness and impaired psychomotor performance.
How serious is the interaction between Melatonin and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduced alertness, particularly at treatment initiation or dose increases. Advise patients to avoid driving and other hazardous activities.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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