Drug interactions
Melatonin + Shepherd's purse
Severity: Minor
Melatonin and Shepherd's purse: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shepherd's purse is an herbal product with little established sedative effect. Any additive sedation with melatonin is speculative.
What this interaction means in plain words
Melatonin and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not established; possible weak additive sedation.
What to do
No specific action is needed. Advise patients to report unusual drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Shepherd's purse?
MediHelp rates the interaction as minor. Melatonin and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shepherd's purse is an herbal product with little established sedative effect. Any additive sedation with melatonin is speculative.
How serious is the interaction between Melatonin and Shepherd's purse?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Advise patients to report unusual drowsiness.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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