Drug interactions
Melatonin + Viloxazine
Severity: Moderate
Melatonin and Viloxazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Viloxazine is a strong CYP1A2 inhibitor and melatonin is cleared mainly via CYP1A2. Melatonin exposure may rise substantially, increasing drowsiness.
What this interaction means in plain words
Melatonin and Viloxazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Melatonin belongs to Gastrointestinal Tract; Viloxazine belongs to Central Nervous System.
Why it happens
Strong CYP1A2 inhibition by viloxazine reduces melatonin clearance.
What to do
Use a low melatonin dose and monitor for excessive sedation, or avoid melatonin during viloxazine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Viloxazine?
MediHelp rates the interaction as moderate. Melatonin and Viloxazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Viloxazine is a strong CYP1A2 inhibitor and melatonin is cleared mainly via CYP1A2. Melatonin exposure may rise substantially, increasing drowsiness.
How serious is the interaction between Melatonin and Viloxazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a low melatonin dose and monitor for excessive sedation, or avoid melatonin during viloxazine therapy.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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