Drug interactions
Meloxicam + Moxifloxacin
Severity: Moderate
Meloxicam and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin can lower the seizure threshold, and NSAID coadministration may add to the risk of CNS stimulation and convulsions. This matters mainly in patients with predisposing neurological conditions.
What this interaction means in plain words
Meloxicam and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, possibly potentiated by NSAIDs.
What to do
Avoid in patients with epilepsy or other seizure risk factors, choosing a different antibiotic if feasible. Stop moxifloxacin if neurological symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Meloxicam with Moxifloxacin?
MediHelp rates the interaction as moderate. Meloxicam and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin can lower the seizure threshold, and NSAID coadministration may add to the risk of CNS stimulation and convulsions. This matters mainly in patients with predisposing neurological conditions.
How serious is the interaction between Meloxicam and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or other seizure risk factors, choosing a different antibiotic if feasible. Stop moxifloxacin if neurological symptoms develop.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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