Drug interactions
Meloxicam + Pegaspargase
Severity: Moderate
Meloxicam and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can reduce clotting factor synthesis and cause coagulopathy, hypofibrinogenemia and thrombocytopenia. Meloxicam adds platelet inhibition and gastrointestinal mucosal injury, so bleeding risk is increased.
What this interaction means in plain words
Meloxicam and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive hemostatic impairment: asparaginase-related coagulation factor depletion plus NSAID antiplatelet effect.
What to do
Avoid NSAIDs during pegaspargase therapy when possible and monitor platelets and coagulation parameters. Use paracetamol for analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Meloxicam with Pegaspargase?
MediHelp rates the interaction as moderate. Meloxicam and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can reduce clotting factor synthesis and cause coagulopathy, hypofibrinogenemia and thrombocytopenia. Meloxicam adds platelet inhibition and gastrointestinal mucosal injury, so bleeding risk is increased.
How serious is the interaction between Meloxicam and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during pegaspargase therapy when possible and monitor platelets and coagulation parameters. Use paracetamol for analgesia.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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