Drug interactions
Meloxicam + Voriconazole
Severity: Moderate
Meloxicam and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C9 and may increase meloxicam exposure, increasing the risk of GI, renal and cardiovascular NSAID adverse effects. The magnitude is usually modest but meaningful in at-risk patients.
What this interaction means in plain words
Meloxicam and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9-mediated metabolism of meloxicam.
What to do
Monitor for NSAID adverse effects such as GI bleeding and renal impairment, and consider reducing the meloxicam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Meloxicam with Voriconazole?
MediHelp rates the interaction as moderate. Meloxicam and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP2C9 and may increase meloxicam exposure, increasing the risk of GI, renal and cardiovascular NSAID adverse effects. The magnitude is usually modest but meaningful in at-risk patients.
How serious is the interaction between Meloxicam and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects such as GI bleeding and renal impairment, and consider reducing the meloxicam dose.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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