Drug interactions
Melphalan + Trastuzumab deruxtecan
Severity: Moderate
Melphalan and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, and trastuzumab deruxtecan commonly causes neutropenia and anemia. Combining them may increase the severity of cytopenias and infection risk.
What this interaction means in plain words
Melphalan and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Melphalan belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts frequently and delay or reduce doses for significant neutropenia or anemia. Provide supportive care such as growth factors where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicated
- Bcg vaccine live + Melphalan Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicated
- Measles mumps and rubella vaccine live + Melphalan Contraindicated
- Measles mumps and rubella vaccine + Melphalan Contraindicated
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Melphalan with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Melphalan and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, and trastuzumab deruxtecan commonly causes neutropenia and anemia. Combining them may increase the severity of cytopenias and infection risk.
How serious is the interaction between Melphalan and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and delay or reduce doses for significant neutropenia or anemia. Provide supportive care such as growth factors where appropriate.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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