Drug interactions
Memantine + Metformin-pioglitazone
Severity: Minor
Memantine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is renally eliminated by tubular secretion through cationic transport and could compete with metformin. The clinical effect is expected to be small, though both drugs accumulate in renal impairment.
What this interaction means in plain words
Memantine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible competition for renal tubular cationic transport reduces clearance of one or both drugs.
What to do
No routine adjustment is needed; monitor renal function and glucose control, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Memantine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is renally eliminated by tubular secretion through cationic transport and could compete with metformin. The clinical effect is expected to be small, though both drugs accumulate in renal impairment.
How serious is the interaction between Memantine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and glucose control, especially in older patients.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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