Drug interactions
Memantine + Metformin-repaglinide
Severity: Minor
Memantine and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is renally secreted by cationic transport and could compete with metformin for elimination. Any increase in metformin exposure is expected to be small.
What this interaction means in plain words
Memantine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Possible competition for renal tubular cationic transporters, reducing metformin clearance.
What to do
No routine change is needed. Monitor renal function and glycemic control in older patients or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Metformin-repaglinide?
MediHelp rates the interaction as minor. Memantine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is renally secreted by cationic transport and could compete with metformin for elimination. Any increase in metformin exposure is expected to be small.
How serious is the interaction between Memantine and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor renal function and glycemic control in older patients or those with renal impairment.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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