Drug interactions
Memantine + Triamterene
Severity: Minor
Memantine and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are cationic drugs eliminated by renal tubular secretion, so they may compete for transport. Memantine exposure could rise modestly, though clinical significance is uncertain; urine alkalinization is the more relevant concern for memantine.
What this interaction means in plain words
Memantine and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine belongs to Central Nervous System; Triamterene belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular cationic secretion transporters.
What to do
No routine change needed; watch for memantine adverse effects such as dizziness or confusion, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Triamterene?
MediHelp rates the interaction as minor. Memantine and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are cationic drugs eliminated by renal tubular secretion, so they may compete for transport. Memantine exposure could rise modestly, though clinical significance is uncertain; urine alkalinization is the more relevant concern for memantine.
How serious is the interaction between Memantine and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; watch for memantine adverse effects such as dizziness or confusion, especially in renal impairment.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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