Drug interactions
Memantine + Vandetanib
Severity: Minor
Memantine and Vandetanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits OCT2 and may reduce the renal secretion of memantine, increasing its concentrations. This may lead to more CNS adverse effects.
What this interaction means in plain words
Memantine and Vandetanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Vandetanib inhibits OCT2-mediated tubular secretion of memantine.
What to do
Monitor for dizziness, confusion and somnolence, and reduce the memantine dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Memantine with Vandetanib?
MediHelp rates the interaction as minor. Memantine and Vandetanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vandetanib inhibits OCT2 and may reduce the renal secretion of memantine, increasing its concentrations. This may lead to more CNS adverse effects.
How serious is the interaction between Memantine and Vandetanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and somnolence, and reduce the memantine dose if toxicity develops.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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