Drug interactions
Memantine-donepezil + Mifepristone
Severity: Moderate
Memantine-donepezil and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can prolong the QT interval, particularly at the higher doses used for Cushing syndrome. Donepezil may add to this effect, and mifepristone inhibits CYP3A4, which may raise donepezil exposure.
What this interaction means in plain words
Memantine-donepezil and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by mifepristone.
What to do
Check a baseline ECG and electrolytes, especially with long-term high-dose mifepristone, and monitor the QTc. Watch for cholinergic effects of donepezil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Mifepristone?
MediHelp rates the interaction as moderate. Memantine-donepezil and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone can prolong the QT interval, particularly at the higher doses used for Cushing syndrome. Donepezil may add to this effect, and mifepristone inhibits CYP3A4, which may raise donepezil exposure.
How serious is the interaction between Memantine-donepezil and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, especially with long-term high-dose mifepristone, and monitor the QTc. Watch for cholinergic effects of donepezil.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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