Drug interactions
Memantine-donepezil + Pilocarpine
Severity: Moderate
Memantine-donepezil and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a direct muscarinic agonist, and donepezil raises acetylcholine levels, so cholinergic effects are additive. Patients may have more sweating, salivation, GI upset, bradycardia and bronchospasm.
What this interaction means in plain words
Memantine-donepezil and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive muscarinic stimulation from direct agonism and cholinesterase inhibition.
What to do
Monitor for cholinergic adverse effects, especially heart rate and respiratory symptoms. Reduce the pilocarpine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Memantine-donepezil and Pilocarpine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Memantine-donepezil with Pilocarpine?
MediHelp rates the interaction as moderate. Memantine-donepezil and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a direct muscarinic agonist, and donepezil raises acetylcholine levels, so cholinergic effects are additive. Patients may have more sweating, salivation, GI upset, bradycardia and bronchospasm.
How serious is the interaction between Memantine-donepezil and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects, especially heart rate and respiratory symptoms. Reduce the pilocarpine dose if they occur.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
