Drug interactions
Memantine-donepezil + Ramelteon
Severity: Minor
Memantine-donepezil and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil has been reported to increase ramelteon exposure substantially in a pharmacokinetic study. This may increase sedation, dizziness and next-day somnolence.
What this interaction means in plain words
Memantine-donepezil and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
The mechanism is not well established; possible effect on ramelteon metabolism.
What to do
Start with the standard ramelteon dose and monitor for excess sedation or dizziness. Reduce the dose if these effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Memantine-donepezil with Ramelteon?
MediHelp rates the interaction as minor. Memantine-donepezil and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Donepezil has been reported to increase ramelteon exposure substantially in a pharmacokinetic study. This may increase sedation, dizziness and next-day somnolence.
How serious is the interaction between Memantine-donepezil and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the standard ramelteon dose and monitor for excess sedation or dizziness. Reduce the dose if these effects occur.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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