Drug interactions
Memantine-donepezil + Tafenoquine
Severity: Moderate
Memantine-donepezil and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits renal transporters OCT2 and MATE in vitro, which may reduce the renal tubular secretion of memantine and raise its plasma levels. Higher memantine exposure could increase dizziness, confusion and other CNS effects.
What this interaction means in plain words
Memantine-donepezil and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Tafenoquine belongs to Anti Parasitic.
Why it happens
Inhibition of OCT2 and MATE-mediated renal tubular secretion of memantine.
What to do
Monitor for memantine adverse effects such as dizziness, confusion and agitation during tafenoquine use. Consider reducing the memantine dose if toxicity appears, especially with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Memantine-donepezil with Tafenoquine?
MediHelp rates the interaction as moderate. Memantine-donepezil and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits renal transporters OCT2 and MATE in vitro, which may reduce the renal tubular secretion of memantine and raise its plasma levels. Higher memantine exposure could increase dizziness, confusion and other CNS effects.
How serious is the interaction between Memantine-donepezil and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for memantine adverse effects such as dizziness, confusion and agitation during tafenoquine use. Consider reducing the memantine dose if toxicity appears, especially with renal impairment.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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