Drug interactions
Memantine-donepezil + Trilaciclib
Severity: Moderate
Memantine-donepezil and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal transporters (OCT2, MATE1, MATE2-K) involved in the tubular secretion of memantine. This can raise memantine exposure and increase dose-related effects such as dizziness, confusion, agitation and seizures. The legacy suggestion that levels fall is not mechanistically consistent.
What this interaction means in plain words
Memantine-donepezil and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Trilaciclib belongs to Oncology.
Why it happens
Inhibition of OCT2 and MATE1/MATE2-K reduces renal tubular secretion of memantine and increases its plasma concentration.
What to do
Monitor for memantine adverse effects such as dizziness, confusion and agitation on days of trilaciclib infusion. Consider reducing the memantine dose if toxicity occurs, particularly in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Memantine-donepezil with Trilaciclib?
MediHelp rates the interaction as moderate. Memantine-donepezil and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits renal transporters (OCT2, MATE1, MATE2-K) involved in the tubular secretion of memantine. This can raise memantine exposure and increase dose-related effects such as dizziness, confusion, agitation and seizures. The legacy suggestion that levels fall is not mechanistically consistent.
How serious is the interaction between Memantine-donepezil and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for memantine adverse effects such as dizziness, confusion and agitation on days of trilaciclib infusion. Consider reducing the memantine dose if toxicity occurs, particularly in renal impairment.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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