Drug interactions
Memantine-donepezil + Vardenafil
Severity: Moderate
Memantine-donepezil and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil can prolong the QT interval modestly, and donepezil has been linked to QT prolongation and torsades. Co-use may add to arrhythmia risk, particularly in older patients or those with heart disease.
What this interaction means in plain words
Memantine-donepezil and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Check ECG in patients with cardiac risk factors or a history of QT prolongation. Correct electrolytes and consider an alternative erectile dysfunction agent if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Vardenafil?
MediHelp rates the interaction as moderate. Memantine-donepezil and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil can prolong the QT interval modestly, and donepezil has been linked to QT prolongation and torsades. Co-use may add to arrhythmia risk, particularly in older patients or those with heart disease.
How serious is the interaction between Memantine-donepezil and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG in patients with cardiac risk factors or a history of QT prolongation. Correct electrolytes and consider an alternative erectile dysfunction agent if QTc is prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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