Drug interactions
Memantine-donepezil + Verapamil
Severity: Moderate
Memantine-donepezil and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and may modestly increase donepezil levels. Donepezil can also add to the bradycardic effect of verapamil, and memantine may compete for renal tubular secretion, though the effect on verapamil is probably small.
What this interaction means in plain words
Memantine-donepezil and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by verapamil raises donepezil exposure, and additive negative chronotropic effects occur pharmacodynamically.
What to do
Monitor heart rate and ECG for bradycardia or AV block, particularly in older patients or those with conduction disease. Watch for cholinergic adverse effects and reduce the donepezil dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Memantine-donepezil and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Memantine-donepezil with Verapamil?
MediHelp rates the interaction as moderate. Memantine-donepezil and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and may modestly increase donepezil levels. Donepezil can also add to the bradycardic effect of verapamil, and memantine may compete for renal tubular secretion, though the effect on verapamil is probably small.
How serious is the interaction between Memantine-donepezil and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG for bradycardia or AV block, particularly in older patients or those with conduction disease. Watch for cholinergic adverse effects and reduce the donepezil dose if they occur.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
