Drug interactions
Memantine-donepezil + Zafirlukast
Severity: Minor
Memantine-donepezil and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast has been reported to inhibit CYP3A4 in vitro, so it could slightly raise donepezil exposure. Clinically relevant effects are not well established and are expected to be small.
What this interaction means in plain words
Memantine-donepezil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by zafirlukast reducing donepezil clearance.
What to do
No dose adjustment is usually needed. Be alert for increased cholinergic effects such as nausea or bradycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Memantine-donepezil with Zafirlukast?
MediHelp rates the interaction as minor. Memantine-donepezil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast has been reported to inhibit CYP3A4 in vitro, so it could slightly raise donepezil exposure. Clinically relevant effects are not well established and are expected to be small.
How serious is the interaction between Memantine-donepezil and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Be alert for increased cholinergic effects such as nausea or bradycardia.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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