Drug interactions
Meningococcal group b vaccine + Temsirolimus
Severity: Minor
Meningococcal group b vaccine and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus-related immunosuppression may reduce the antibody response to the non-live meningococcal B vaccine. The vaccine can still be given, but protection may be incomplete.
What this interaction means in plain words
Meningococcal group b vaccine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
mTOR inhibition impairs lymphocyte proliferation and so reduces the immune response to vaccine antigens.
What to do
Vaccinate if indicated, ideally before starting temsirolimus, and consider checking response or adhering to additional-dose schedules where recommended.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Meningococcal group b vaccine with Temsirolimus?
MediHelp rates the interaction as minor. Meningococcal group b vaccine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temsirolimus-related immunosuppression may reduce the antibody response to the non-live meningococcal B vaccine. The vaccine can still be given, but protection may be incomplete.
How serious is the interaction between Meningococcal group b vaccine and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate if indicated, ideally before starting temsirolimus, and consider checking response or adhering to additional-dose schedules where recommended.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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