Drug interactions
Meperidine + Pimavanserin
Severity: Moderate
Meperidine and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin is a 5-HT2A inverse agonist that can cause somnolence, and meperidine adds CNS depression. Meperidine's serotonergic activity makes serotonin toxicity theoretically possible, but evidence is limited.
What this interaction means in plain words
Meperidine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive CNS depression with a theoretical serotonergic pharmacodynamic interaction.
What to do
Monitor for excessive sedation and for features of serotonin toxicity when starting or increasing either drug. Reduce doses if drowsiness is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Meperidine with Pimavanserin?
MediHelp rates the interaction as moderate. Meperidine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin is a 5-HT2A inverse agonist that can cause somnolence, and meperidine adds CNS depression. Meperidine's serotonergic activity makes serotonin toxicity theoretically possible, but evidence is limited.
How serious is the interaction between Meperidine and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and for features of serotonin toxicity when starting or increasing either drug. Reduce doses if drowsiness is significant.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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