Drug interactions
Meperidine + Safinamide
Severity: Contraindicated
Meperidine and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide labeling contraindicates meperidine because of the risk of serotonin syndrome. The combination can cause life-threatening hyperthermia, agitation and autonomic instability.
What this interaction means in plain words
Meperidine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meperidine belongs to Musculoskeletal; Safinamide belongs to Central Nervous System.
Why it happens
MAO-B inhibition plus meperidine's serotonin reuptake inhibition.
What to do
Do not co-administer; use a non-serotonergic analgesic. Allow the labeled washout interval between the drugs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Meperidine with Safinamide?
MediHelp rates the interaction as contraindicated. Meperidine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide labeling contraindicates meperidine because of the risk of serotonin syndrome. The combination can cause life-threatening hyperthermia, agitation and autonomic instability.
How serious is the interaction between Meperidine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-serotonergic analgesic. Allow the labeled washout interval between the drugs.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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