Drug interactions
Meprobamate + Modafinil
Severity: Minor
Meprobamate and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic whose effects oppose modafinil. Modafinil may weakly induce CYP3A4, but meprobamate clearance is not strongly CYP-dependent, so the interaction is mainly pharmacodynamic.
What this interaction means in plain words
Meprobamate and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic CNS effects.
What to do
Monitor sedation and alertness and avoid using modafinil to mask meprobamate sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Meprobamate with Modafinil?
MediHelp rates the interaction as minor. Meprobamate and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meprobamate is a sedative-anxiolytic whose effects oppose modafinil. Modafinil may weakly induce CYP3A4, but meprobamate clearance is not strongly CYP-dependent, so the interaction is mainly pharmacodynamic.
How serious is the interaction between Meprobamate and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and alertness and avoid using modafinil to mask meprobamate sedation.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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