Drug interactions
Meprobamate + Pregabalin
Severity: Moderate
Meprobamate and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic and pregabalin also causes sedation and dizziness, so the combination can produce additive drowsiness, impaired coordination and respiratory depression. Older patients and those with lung disease are most at risk.
What this interaction means in plain words
Meprobamate and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective doses and monitor for sedation, confusion and respiratory depression. Reduce the dose of one or both drugs if excessive drowsiness appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Meprobamate with Pregabalin?
MediHelp rates the interaction as moderate. Meprobamate and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic and pregabalin also causes sedation and dizziness, so the combination can produce additive drowsiness, impaired coordination and respiratory depression. Older patients and those with lung disease are most at risk.
How serious is the interaction between Meprobamate and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, confusion and respiratory depression. Reduce the dose of one or both drugs if excessive drowsiness appears.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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