Drug interactions
Meprobamate + Sevoflurane
Severity: Moderate
Meprobamate and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative anxiolytic whose CNS depressant effects add to those of sevoflurane. Patients may be more deeply sedated with a greater risk of hypotension and respiratory depression.
What this interaction means in plain words
Meprobamate and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with meprobamate acting partly via GABA-A modulation.
What to do
Lower the anesthetic dose according to clinical response and monitor sedation and ventilation through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Meprobamate with Sevoflurane?
MediHelp rates the interaction as moderate. Meprobamate and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative anxiolytic whose CNS depressant effects add to those of sevoflurane. Patients may be more deeply sedated with a greater risk of hypotension and respiratory depression.
How serious is the interaction between Meprobamate and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the anesthetic dose according to clinical response and monitor sedation and ventilation through recovery.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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