Drug interactions
Mercaptopurine + Ozanimod
Severity: Moderate
Mercaptopurine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod reduces circulating lymphocytes and mercaptopurine suppresses lymphocyte and marrow function. The combination may add to immunosuppression and infection risk, including after one drug is stopped.
What this interaction means in plain words
Mercaptopurine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mercaptopurine belongs to Oncology; Ozanimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression via lymphocyte sequestration by S1P receptor modulation and antimetabolite effects.
What to do
Monitor for infection and check lymphocyte and total blood counts. Account for the lingering effects of each drug when switching therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Mercaptopurine with Ozanimod?
MediHelp rates the interaction as moderate. Mercaptopurine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod reduces circulating lymphocytes and mercaptopurine suppresses lymphocyte and marrow function. The combination may add to immunosuppression and infection risk, including after one drug is stopped.
How serious is the interaction between Mercaptopurine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check lymphocyte and total blood counts. Account for the lingering effects of each drug when switching therapies.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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