Drug interactions
Mesalamine + Nizatidine
Severity: Minor
Mesalamine and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some delayed-release mesalamine products release drug in a pH-dependent manner. Raising gastric pH with an H2 blocker may alter release, though the effect is smaller than with proton pump inhibitors and clinical impact is uncertain.
What this interaction means in plain words
Mesalamine and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mesalamine belongs to Gastrointestinal Tract; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH may alter pH-dependent coating dissolution of certain mesalamine formulations.
What to do
No routine action is needed; monitor disease control if using a pH-dependent mesalamine product.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Mesalamine with Nizatidine?
MediHelp rates the interaction as minor. Mesalamine and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some delayed-release mesalamine products release drug in a pH-dependent manner. Raising gastric pH with an H2 blocker may alter release, though the effect is smaller than with proton pump inhibitors and clinical impact is uncertain.
How serious is the interaction between Mesalamine and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor disease control if using a pH-dependent mesalamine product.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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