Drug interactions
Mesalamine + Oxaprozin
Severity: Moderate
Mesalamine and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine can rarely cause interstitial nephritis and renal impairment, and NSAIDs can reduce renal perfusion and cause nephrotoxicity. Using them together may increase the risk of kidney injury.
What this interaction means in plain words
Mesalamine and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mesalamine belongs to Gastrointestinal Tract; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive renal toxicity: NSAID inhibition of prostaglandin-mediated renal perfusion plus mesalamine-associated interstitial nephritis.
What to do
Monitor serum creatinine and urinalysis at baseline and periodically, and avoid the NSAID in patients with existing renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Mesalamine with Oxaprozin?
MediHelp rates the interaction as moderate. Mesalamine and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine can rarely cause interstitial nephritis and renal impairment, and NSAIDs can reduce renal perfusion and cause nephrotoxicity. Using them together may increase the risk of kidney injury.
How serious is the interaction between Mesalamine and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urinalysis at baseline and periodically, and avoid the NSAID in patients with existing renal impairment or dehydration.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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