Drug interactions
Mesalamine + Pivmecillinam
Severity: Minor
Mesalamine and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins are cleared by renal tubular secretion, which salicylates can compete with. With mesalamine, the low systemic salicylate exposure makes a meaningful rise in mecillinam levels unlikely.
What this interaction means in plain words
Mesalamine and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mesalamine belongs to Gastrointestinal Tract; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Theoretical competition for renal tubular organic anion secretion, extrapolated from salicylates.
What to do
No dose adjustment is usually needed. Be aware of the possibility of higher beta-lactam levels in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Mesalamine with Pivmecillinam?
MediHelp rates the interaction as minor. Mesalamine and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins are cleared by renal tubular secretion, which salicylates can compete with. With mesalamine, the low systemic salicylate exposure makes a meaningful rise in mecillinam levels unlikely.
How serious is the interaction between Mesalamine and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Be aware of the possibility of higher beta-lactam levels in patients with renal impairment.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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